The Food and Drug Administration FDA has issued a warning stating that women taking the prescription blood thinner warfarin Coumadin should consult their doctor or pharmacist before using over-the-counter vaginal creams containing the antifungal drug miconazole because of an increased risk of bleeding or bruising. Miconazole is an active ingredient in many over-the-counter creams and suppositories used to treat vaginal yeast infections. Doctors were already aware of adverse reactions between warfarin and systemically administered miconazole. This warning urges women to beware of creams and suppositories as well. The warning was issued in response to two reports of abnormal blood clotting tests in women taking the anticoagulant warfarin who used vaginal miconazole. In addition to the abnormal blood-clotting test, one of the two women also developed bruises, bleeding gums, and a nosebleed.
Possible warfarin side effects and signs of a blood clot
Management of Heavy Menstrual Bleeding on Anticoagulation
Warfarin may cause severe bleeding that can be life-threatening and even cause death. Tell your doctor if you have or have ever had a blood or bleeding disorder; bleeding problems, especially in your stomach or your esophagus tube from the throat to the stomach , intestines, urinary tract or bladder, or lungs; high blood pressure; heart attack; angina chest pain or pressure ; heart disease; pericarditis swelling of the lining sac around the heart ; endocarditis infection of one or more heart valves ; a stroke or ministroke; aneurysm weakening or tearing of an artery or vein ; anemia low number of red blood cells in the blood ; cancer; chronic diarrhea; or kidney, or liver disease. Also tell your doctor if you fall often or have had a recent serious injury or surgery. Bleeding is more likely during warfarin treatment for people over 65 years of age, and it is also more likely during the first month of warfarin treatment.
Abnormal vaginal bleeding in women with venous thromboembolism treated with apixaban or warfarin.
Every woman's period is different. Many women have abnormal bleeding between their periods at some point in their lives. Abnormal bleeding occurs when you have:. Irregular menstruation; Heavy, prolonged, or irregular periods; Menorrhagia; Polymenorrhea; Metrorrhagia and other menstrual conditions; Abnormal menstrual periods; Abnormal vaginal bleeding. Abnormal bleeding is often linked to failure of regular ovulation anovulation.
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